The CogMission Approach

At CogMission, we use a Functional Medicine approach to identify and treat the underlying causes of cognitive decline. Although we use the principles and functional testing outlined by the Bredesen Protocol, we have more than 40 years combined experience in treating complex conditions.

Even with great advanced in modern medicine today, there is still no simple solution to treating cognitive decline.  Because of the complexity of the illness, it has been impossible to find that magic drug that would end this debilitating condition.  Despite billions of pounds being spent on trying to find a cure, western medicine are no further forward.

Dementia develops as a result of many contributing factors including genetics, hormonal factors, nutritional deficiencies, toxicity to name but just a few.  To find solutions for slowing down and reversing this, we must find what the individual contributors are for each person.  Although we can gather a great deal of information through question taking, we do rely heavily on extensive laboratory testing to find all the possible contributors.

Finding the right solution for each person

Once we have a full picture of what has led to the development of the condition, we can then work on prioritising treatments so that we gain a synergystic effect. For example, sometimes patients present with a large number of contributors. Our challenge is to find the simplest but most effective strategy that will have the biggest effect.

Although everything we recommend and prescribe is natural, we work very closely with healthcare providers to ensure that our treatment strategies support the current treatments provided by your doctor.

We also have a very strong focus on preventative health and although our services are usually engaged in helping patients who already have a diagnosis, we often work with patients who have a genetic predisposition to prevent the onset of mental decline.

Flowers in a wooden Pestle and Mortar

Our work involves pulling together complex information in order to “type” the drivers for the cognitive decline. Often patients will display a combination of these patterns:

Type 1- inflammatory

Inflammation is triggered in the brain, leading to a change in connections between neurons, and then these neurons dying.  There are many possible triggers of neuro-inflammation, including high blood sugar, insulin resistance and increased intestinal permeability (leaky gut). It is vital to Identify the triggers of inflammation and remove them which can lead to the growth of new connections between neurons, and the growth of new neurons especially in the memory centre of the brain.

Type 1.5 – glycotoxic

This type is a combination of Types 1 and 2. It is due to the inflammatory effect of high blood sugar combined with high insulin levels in the blood but not working right through to the cells.

Diagram of blood cells in a vein

Type 2 - atrophic

The loss of hormones and nutrients that cause neuron growth and support their function. These hormones include growth hormone, IGF-1, testosterone, estradiol, progesterone, tri-iodothyronine (T3), calcitriol (vitamin D). Nutrients include magnesium, zinc, calcium, potassium, and vitamins A, B2, B6, B9, B12, C, E. Identifying missing hormones and nutrients, and replacing them, can again trigger the growth of new connections between neurons, and the growth of new neurons.

Type 3 – toxic

This type is caused by infections and toxins that trigger neuroinflammation and nerve cell dysfunction and death. Infections include viral (HSV, EBV, CMV, HSV6, Borrelia, Babesia, Bartonella, fungal, MARCoNS). Toxins include mercury (from dental amalgams and fish), aluminum (and other heavy metals and minerals), mycotoxins (from fungi in the environment or growing on or in the body (in the biofilm on foreign objects – dental implants, joint implants, breast implants). Common mycotoxins are trichothenes (Stachybotrys), Ochratoxin A (Penicillium), aflatoxin (Aspergillus). If we Remove the source of the infection or toxicity and repair the damage done this allows nerve cells to regrow, and cognitive function to improve.

Type 4 – vascular

Vascular dementia (causing 20% of all dementias) is caused by damage to the tiny capillaries that supply blood and nutrients to, and remove waste products from, the brain. There are many factors that cause damage to these blood vessels, such as high homocysteine, high glucose, high lipoprotein a, high CRP, high endotoxin (LPS), and low testosterone, estradiol, progesterone. Removing the damaging factors and adding the supportive factors leads to improved blood supply and better brain functioning.

Type 5 – traumatic

One large, or multiple small physical or chemical traumas to the brain can promote the onset of a neuroinflammatory cascade that leads over time to nerve cell dysfunction and death and worsening cognitive function.

Identifying which factors apply to an individual with cognitive decline, and reversing them, leads to improvement in cognitive function, and the reversal of subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and if caught early enough, even Alzheimer’s Disease.